Piperidin-4-ol → HCID 11583994, compound

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-[(4-{[3-ethyl-4-(pyridin-2-ylmethoxy)phenyl]amino}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]ethyl methanesulfonate (prepared as described in Example 19) and 4-hydroxypiperidine to give the title compound in 46% yield; NMR Spectrum: 1.20 (t, 3H), 1.32-1.39 (m, 2H), 1.66-1.69 (m, 2H), 2.16 (t, 2H), 2.67 (q, 2H), 2.75-2.81 (m, 4H), 4.39 (t, 2H), 4.52 (d, 1H), 5.20 (s, 2H), 7.01 (d, 1H), 7.34-7.40 (m, 1H), 7.44 (d, 1H), 7.50-7.55 (m, 2H), 7.85 (td, 1H), 8.24 (s, 1H), 8.25 (s, 1H), 8.59 (d, 1H); Mass Spectrum: 490 (MH+).

Provenance & Evidence