HCID 21495107, compound → HCID 67020662, compound

HRID 550515Notes

Reaction equation

HRID 550515 reaction equation
[C:1]([C:3]1[C:4]([O:13][CH2:14][CH2:15][OH:16])=[N:5][NH:6][C:7]=1[N:8]=[CH:9][N:10](C)C)#[N:2].[CH3:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][C:24]=1[O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)N>>[CH2:26]([O:25][C:24]1[CH:23]=[CH:22][C:20]([NH:2][C:1]2[N:10]=[CH:9][N:8]=[C:7]3[NH:6][N:5]=[C:4]([O:13][CH2:14][CH2:15][OH:16])[C:3]=23)=[CH:19][C:18]=1[CH3:17])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 21495107HCID 21495107, compoundHCID 67020529N'-[4-cyano-3-(2-hydroxyethoxy)-1H-pyrazol-5-yl]-N,N-dimethylimidoformamide

Product 1

HCID 67020662HCID 67020662, compoundYield 64.2%

Procedure

The procedure described in Example 1 was repeated using N′-[4-cyano-3-(2-hydroxyethoxy)-1H-pyrazol-5-yl]-N,N-dimethylimidoformamide (2.0 g, 8.96 mmol) and 3-methyl-4-benzyloxyaniline (2.1 g, 9.87 mmol) to give the title compound as a white solid (2.25 g, 64%); NMR Spectrum: 2.23 (s, 3H), 3.79 (t, 2H), 4.30 (t, 2H), 5.15 (s, 2H), 7.03 (d, 1H), 7.32-7.48 (m, 7H), 8.21 (s, 1H), 8.33 (s, 1H); Mass Spectrum: 392 (MH+).

Sources & evidence

ORD record
ord-fe8b3bb808b245699c2596e2c191d79b
Source dataset
uspto-grants-2011_05
Patent number
US07947676B2

Reaction notes

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