Piperidin-4-ol → HCID 67020809, compound

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-[(4-{[4-(benzyloxy)-3-methylphenyl]amino}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]ethyl methanesulfonate (prepared as described in Example 110) and 4-hydroxypiperidine to give the title compound in 60% yield; NMR Spectrum: 1.34-1.40 (m, 2H), 1.66-1.69 (m, 2H), 2.16 (t, 2H), 2.22 (s, 3H), 2.75-2.81 (m, 4H), 3.40-3.43 (m, 1H), 4.39 (t, 2H), 4.53 (d, 1H), 5.13 (s, 2H), 7.01 (d, 1H), 7.32-7.48 (m, 7H), 8.19 (s, 1H), 8.24 (s, 1H); Mass Spectrum: 475 (MH+).

Provenance & Evidence