1,4-Oxazepane → n-[4-(Benzyloxy)-3-methylphenyl]-3-[2-(1,4-oxazepan-4-yl)ethoxy]-1h-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-[(4-{[4-(benzyloxy)-3-methylphenyl]amino}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]ethyl methanesulfonate (prepared as described in Example 110) and homomorpholine to give the title compound in 22% yield; NMR Spectrum: 1.75-1.79 (m, 2H), 2.22 (s, 3H), 2.76-2.78 (m, 4H), 2.97 (t, 2H), 3.57-3.59 (m, 2H), 3.62-3.64 (m, 2H), 4.40 (t, 2H), 5.13 (s, 2H), 7.02 (d, 1H), 7.32-7.48 (m, 7H), 8.21 (s, 1H), 8.24 (s, 1H); Mass Spectrum: 475 (MH+).

Provenance & Evidence