HCID 11525981, compound → HCID 67020565, compound

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-{[4-({4-[(3-fluorobenzyl)oxy]-3-methylphenyl}amino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy}ethyl methanesulfonate (prepared as described in Example 21) and homomorpholine to give the title compound in 25% yield; NMR Spectrum: 1.74-1.79 (m, 2H), 2.23 (s, 3H), 2.76-2.79 (m, 4H), 2.98 (t, 2H), 3.57-3.59 (m, 2H), 3.62-3.64 (m, 2H), 4.40 (t, 2H), 5.16 (s, 2H), 7.00 (d, 1H), 7.16 (td, 1H), 7.28-7.33 (m, 2H), 7.44-7.47 (m, 3H), 8.17 (s, 1H), 8.24 (s, 1H); Mass Spectrum: 493 (MH+).

Provenance & Evidence