4-Methoxypiperidine → N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-methoxypiperidin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Reaction Steps

The procedure described in Example 23 was repeated using 3-(2-chloroethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (prepared as described in Example 13) and 4-methoxypiperidine (prepared as described in Example 118, starting material) to give the title compound in 35% yield; NMR Spectrum: 1.35-1.42 (m, 2H), 1.78-1.80 (m, 2H), 2.18-2.22 (m, 2H), 2.77-2.79 (m, 4H), 3.11-3.16 (m, 1H), 3.20 (s, 3H), 4.40 (t, 2H), 5.29 (s, 2H), 7.24 (d, 1H), 7.36-7.38 (m, 1H), 7.55-7.58 (m, 2H), 7.86-7.90 (m, 2H), 8.29 (s, 1H), 8.50 (s, 1H), 8.59 (d, 1H); Mass Spectrum: 510 (MH+).

Provenance & Evidence