HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-(1,1-difluoro-4-penten-1-yl)-4-methyl-5-phenyl-4H-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N,N'-dimethylbenzenecarboximidamide hydrochloride | HCID 12382386 | — |
| Reactant | 5-Hexenoic acid, 2,2-difluoro-, hydrazide | HCID 57691893 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1,1-difluoro-4-penten-1-yl)-4-methyl-5-phenyl-4H-1,2,4-triazole | HCID 57691888 | 10.2% |
Reaction Steps
To a solution of 2,2-difluoro-5-hexenohydrazide (275 mg) in MeOH (8 ml) were added K2CO3 (232 mg) and N,N′-dimethylbenzenecarboximidamide hydrochloride (309 mmol). The solution was heated at reflux for 3 days. Volatiles were evaporated in vacuo and the crude was purified by column chromatography (DCM:MeOH=95 to 5) to give 45 mg of the title compound. MS (m/z): 264[MH]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947683B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-cc55b856928d40e7ac7cf21c40ad1c12 |
| Source note | uspto-grants-2011_05 |