HCID 57691874, compound → HCID 15602726, compound

HRID 550554Notes

Reaction equation

HRID 550554 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:15]([CH3:16])[C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[N:13][N:12]=1)(=O)=O.[F:24][C:25]([F:39])([F:38])[C:26]1[CH:31]=[CH:30][C:29]([C@:32]23[CH2:37][C@H:36]2[CH2:35][NH:34][CH2:33]3)=[CH:28][CH:27]=1>>[ClH:23].[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([C:14]2[N:15]([CH3:16])[C:11]([CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][N:34]3[CH2:35][C@H:36]4[C@:32]([C:29]5[CH:28]=[CH:27][C:26]([C:25]([F:24])([F:39])[F:38])=[CH:31][CH:30]=5)([CH2:37]4)[CH2:33]3)=[N:12][N:13]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 57691874HCID 57691874, compoundHCID 59337591(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

Product 1

HCID 15602726HCID 15602726, compound

Procedure

The title compound was prepared in analogy to the method described in Example 14 in 19 mg yield as a white solid starting from 5-[5-(4-chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]pentyl methanesulfonate (31 mg) and (1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (21 mg ).

Workup

  1. customyield as a white solid

Sources & evidence

ORD record
ord-481780187da645a5acea5eff3fddb4b6
Source dataset
uspto-grants-2011_05
Patent number
US07947683B2

Reaction notes

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