Dimethylformamide dimethyl acetal → HCID 67199434, compound

Participants

Reaction Conditions

Reaction Steps

1 g (4.14 mmol) of N-(3-acetylphenyl)-1-propane-sulfonamide were dissolved in 10 ml of N,N-dimethylformamide. To the resultant solution 2.77 ml (20.74 mmol) of N,N-dimethylformamide dimethyl acetal were added and heated at 150° C. for 2 h. The solvent was removed by reduced pressure distillation to yield an oil, which was treated with a mixture of ethyl acetate-ethyl ether. A small quantity of a solid precipitated which was discarded. The filtrate was evaporated to dryness, dissolved in dichloromethane, and the organic layer was washed with 4×50 ml of water and evaporated to dryness. 1.23 g (yield=96%) of N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-methyl-1-propane-sulfonamide were obtained.

Provenance & Evidence