3-Amino-5-chloropyridine → 3-(5-Chloro-pyridin-3-ylamino)-6-methyl-pyrazine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide

HRID 550580Notes

Reaction equation

HRID 550580 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[C:16](Br)=[N:15][CH:14]=[C:13]([CH3:18])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.[Cl:19][C:20]1[CH:21]=[C:22]([NH2:26])[CH:23]=[N:24][CH:25]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[C:16]([NH:26][C:22]3[CH:23]=[N:24][CH:25]=[C:20]([Cl:19])[CH:21]=3)=[N:15][CH:14]=[C:13]([CH3:18])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 8182573-Amino-5-chloropyridineHCID 866074893-Bromo-6-methyl-pyrazine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide

Product 1

HCID 119966323-(5-Chloro-pyridin-3-ylamino)-6-methyl-pyrazine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide

Procedure

The title compound, MS: m/e=355.1 (M+H+), was prepared in accordance with the general method of example 4, step 2 from 3-bromo-6-methyl-pyrazine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide and 5-chloropyridine-3-amine.

Sources & evidence

ORD record
ord-82540a5b063c420dbf44754aafffbd87
Source dataset
uspto-grants-2011_05
Patent number
US07947685B2

Reaction notes

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