3-Fluoroaniline → 3-(3-Fluoro-phenylamino)-pyrazine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

HRID 550582Notes

Reaction equation

[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15](Br)=[N:14][CH:13]=[CH:12][N:11]=2)=[O:9])[S:5][CH:6]=1.[F:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH:21][C:20]3[CH:22]=[CH:23][CH:24]=[C:18]([F:17])[CH:19]=3)=[N:14][CH:13]=[CH:12][N:11]=2)=[O:9])[S:5][CH:6]=1

Participants

Reactant 2

HCID 97423-Fluoroaniline

HCID 86607490HCID 86607490, compound

Product 1

HCID 119963293-(3-Fluoro-phenylamino)-pyrazine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

Procedure

The title compound, MS: m/e=330.1 (M+H+), was prepared in accordance with the general method of example 4, step 2 from 3-bromo-pyrazine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide and 3-fluoroaniline.

Sources & evidence

ORD record: ord-632ebf8a9b75487eb16fa6a275f68ed5
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947685B2

Reaction notes

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