HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromopyrimidine → 6-Methyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromopyrimidine | HCID 78344 | — |
| Reactant | Ethyl 3-amino-6-methylpyrazine-2-carboxylate | HCID 317738 | — |
| Reactant | 2-Amino-5-fluoropyridine | HCID 2737701 | — |
| Product | 6-Methyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide | HCID 11996475 | — |
Reaction Steps
The title compound, MS: m/e=326.3 (M+H+), was prepared in accordance with the general method of example 10 from 3-amino-6-methyl-pyrazine-2-carboxylic acid ethyl ester (Example C), 5-bromopyrimidine and 2-amino-5-fluoropyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947685B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-c847970dd0f14e25bf8fd20b59ca0d5d |
| Source note | uspto-grants-2011_05 |