HCID 86626331, compound → HCID 86626332, compound

HRID 550597Notes

Reaction equation

HRID 550597 reaction equation
C([O:5][C:6](=[O:28])[C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])[CH2:15][CH2:14]2)=[CH:9][C:8]=1[N+:25]([O-:27])=[O:26])(C)(C)C>ClCCl>[N+:25]([C:8]1[CH:9]=[C:10]([N:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])[CH2:15][CH2:14]2)[CH:11]=[CH:12][C:7]=1[C:6]([OH:28])=[O:5])([O-:27])=[O:26]

Participants

3

Reactant 1

HCID 86626331HCID 86626331, compound

Product 1

HCID 86626332HCID 86626332, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-nitro-4-[4-(2,2,2-trifluoro-acetyl)-piperazin-1-yl]-benzoic acid tert-butyl ester (1.70 g, 4.22 mmol) in dichloromethane (25 mL) trifluoroacetic acid (5 mL) was added. The mixture was stirred at room temperature for 2 h, and then evaporated to give the title compound as yellow solid. 1H-NMR (400 MHz), ppm, DMSO-d6): 13.21 (bs, 1H), 7.78 (d, J=8.9 Hz, 1H), 7.31 (d, J=2.5 Hz, 1H), 7.17 (dd, J1=8.9 Hz, J2=2.5 Hz, 1H), 3.74 (m, 4H), 3.56 (m, 4H).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-d405e2a98da646d3adfea35e74227eee
Source dataset
uspto-grants-2011_05
Patent number
US07947686B2

Reaction notes

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