HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(2-Dimethylamino-ethoxy)-2-nitro-benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-(dimethylamino)ethoxy)-2-nitrobenzoate | HCID 57447330 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(2-Dimethylamino-ethoxy)-2-nitro-benzoic acid hydrochloride | HCID 57447328 | — |
Reaction Steps
To a solution of 4-(2-dimethylamino-ethoxy)-2-nitro-benzoic acid tert-butyl ester (4.53 g, 14.61 mmol) in dioxane (100 mL) was added 37% HCl (25 mL). The mixture was stirred at room temperature for 15 hours, then the suspension was evaporated and the solid dried under vacuum at 50° C. to give the title compound as yellowish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947686B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-8d29d0253dde43d19fbc69ccddaeb97a |
| Source note | uspto-grants-2011_05 |