HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene → 1-[4-(4-Ethoxycarbonyl-2-quinolylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene | HCID 520026 | — |
| Reactant | 2-(4-Aminophenylthio)-4-ethoxycarbonylquinoline | HCID 18971646 | — |
| Product | 1-[4-(4-Ethoxycarbonyl-2-quinolylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)thiourea | HCID 18971676 | 89% |
Reaction Steps
2-(4-aminophenylthio)-4-ethoxycarbonylquinoline (6.0 moles, 2.0 g) and 4-chloro-3-trifluoromethylphenylisothiocyanate (6.0 mmoles, 1.4 g) were reacted according to procedure C to yield 3.0 g, 89% of the title compound. Mass Spec (FD) 561. Calculated for C26H19ClF3N3O2S2 : C, 55.56; H, 3.41; N, 7.48. Found: C, 55.38 H, 3.38; N, 7.36.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624937 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-70cc713a712d4f44814bcc9a506d0034 |
| Source note | uspto-grants-1997_04 |