Acetic Anhydride → N-(2-Thiophen-2-yl-ethyl)-acetamide

HRID 550623Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH2:8].[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][C:9](=[O:11])[CH3:10]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 116521Thiopheneethanamine

Product 1

HCID 21821173N-(2-Thiophen-2-yl-ethyl)-acetamideYield 90%

Procedure

In close analogy to the procedure described above, 2-Thiophen-2-yl-ethylamine is reacted with acetic anhydride to provide the title compound.

Sources & evidence

ORD record: ord-39ea0f98ca09478f885548fb25a503ea
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

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