Acetic Anhydride → N-[2-(5-Methyl-thiophen-2-yl)-ethyl]-acetamide

HRID 550624Notes

Reaction equation

[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][NH2:9])=[CH:4][CH:3]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 147881892-(5-Methyl-2-thienyl)ethanamine

Product 1

HCID 21821174N-[2-(5-Methyl-thiophen-2-yl)-ethyl]-acetamideYield 78%

Procedure

In close analogy to the procedure described above, 2-(5-Methyl-thiophen-2-yl)-ethylamine is reacted with acetic anhydride to provide the title compound.

Sources & evidence

ORD record: ord-79cf946dd0654388ac2177ad04ecac34
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

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