Ethyl trifluoroacetate → 2,2,2-trifluoro-N-[2-(thiophen-2-yl)ethyl]acetamide

HRID 550628Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH2:8].[F:9][C:10]([F:17])([F:16])[C:11](OCC)=[O:12]>>[F:9][C:10]([F:17])([F:16])[C:11]([NH:8][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:12]

Participants

Reactant 2

HCID 9794Ethyl trifluoroacetate

HCID 116521Thiopheneethanamine

Product 1

HCID 571304842,2,2-trifluoro-N-[2-(thiophen-2-yl)ethyl]acetamideYield 86%

Procedure

In close analogy to the procedure described above, 2-Thiophen-2-yl-ethylamine is reacted with ethyl trifluoracetate to provide the. title compound.

Workup

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Sources & evidence

ORD record: ord-5b0027aece1040d094547082759cd9ac
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

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