Phosphorus oxide (P4O10) → 4-methyl-6H,7H-thieno[3,2-c]pyridine

HRID 550630Notes

Reaction equation

HRID 550630 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][C:9](=O)[CH3:10].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:10][C:9]1[C:3]2[CH:4]=[CH:5][S:1][C:2]=2[CH2:6][CH2:7][N:8]=1

Participants

3

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 21821173N-(2-Thiophen-2-yl-ethyl)-acetamide

Product 1

HCID 218211774-methyl-6H,7H-thieno[3,2-c]pyridine

Procedure

In close analogy to the procedure described above, N-(2-Thiophen-2-yl-ethyl)-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record
ord-3708b5c8d4eb495b9ce552051051e37f
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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