6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → (6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(4,4-dimethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

HRID 550651Notes

Reaction equation

HRID 550651 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][C:15]1([CH3:24])[C:20]2[CH:21]=[CH:22][S:23][C:19]=2[CH2:18][CH2:17][NH:16]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH2:17][CH2:18][C:19]4[S:23][CH:22]=[CH:21][C:20]=4[C:15]3([CH3:24])[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 671932164,4-dimethyl-6,7-dihydro-5H-thieno[3,2-c]pyridine

Product 1

HCID 24898543(6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(4,4-dimethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 4,4-dimethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-5439c5fafc76450bb9ef26cdae057986
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

Loading…