4-ethyl-4H,5H,6H,7H-thieno(3,2-c)pyridine → (6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(4-ethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

HRID 550655Notes

Reaction equation

HRID 550655 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH2:14]([CH:16]1[C:21]2[CH:22]=[CH:23][S:24][C:20]=2[CH2:19][CH2:18][NH:17]1)[CH3:15]>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:17]3[CH2:18][CH2:19][C:20]4[S:24][CH:23]=[CH:22][C:21]=4[CH:16]3[CH2:14][CH3:15])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 64852964-ethyl-4H,5H,6H,7H-thieno(3,2-c)pyridineHCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid

Product 1

HCID 24898991(6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(4-ethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanoneYield 60%

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 4-ethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine to provide the title compound.

Sources & evidence

ORD record
ord-806bfe7d68e9446a8805c17875a43cff
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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