6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(4-trifluoromethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

HRID 550656Notes

Reaction equation

HRID 550656 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]([F:26])([F:25])[CH:16]1[C:21]2[CH:22]=[CH:23][S:24][C:20]=2[CH2:19][CH2:18][NH:17]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:17]3[CH2:18][CH2:19][C:20]4[S:24][CH:23]=[CH:22][C:21]=4[CH:16]3[C:15]([F:14])([F:26])[F:25])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 596630934-Trifluoromethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Product 1

HCID 24898767(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(4-trifluoromethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-methanone

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 4-trifluoromethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-28d28ee1f5434223b047e0dd88a348a2
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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