6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24899492, compound

HRID 550663Notes

Reaction equation

HRID 550663 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]1[C:19]2[CH:20]([CH3:24])[NH:21][CH2:22][CH2:23][C:18]=2[S:17][CH:16]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:22][CH2:23][C:18]4[S:17][CH:16]=[C:15]([F:14])[C:19]=4[CH:20]3[CH3:24])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 67192971HCID 67192971, compound

Product 1

HCID 24899492HCID 24899492, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 3-fluoro-4-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-059b6bc7560849a2a81c1885a26c5858
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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