6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → HCID 59663059, compound

HRID 550668Notes

Reaction equation

HRID 550668 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:20]2[CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[S:23][C:19]=2[CH2:18][CH2:17][NH:16]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH2:17][CH2:18][C:19]4[S:23][C:22]([C:24]([F:25])([F:27])[F:26])=[CH:21][C:20]=4[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 67193648HCID 67193648, compound

Product 1

HCID 59663059HCID 59663059, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 4-methyl-2-trifluoromethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-1412df2202d6469c83f0258a503dcd40
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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