6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → HCID 24899751, compound

HRID 550674Notes

Reaction equation

HRID 550674 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[NH:20][CH2:19][C:18]2[CH:21]=[CH:22][O:23][C:17]=2[CH2:16]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:20]3[CH:15]([CH3:14])[CH2:16][C:17]4[O:23][CH:22]=[CH:21][C:18]=4[CH2:19]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 67193278HCID 67193278, compound

Product 1

HCID 24899751HCID 24899751, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6-methyl-4,5,6,7-tetrahydro-furo[3,2-c]pyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-3b373bcdf7a447eda2bafcfa70eefb6d
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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