6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 59663063, compound

HRID 550679Notes

Reaction equation

HRID 550679 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[C:14]1([C:20]2[C:24]3[CH2:25][NH:26][CH2:27][CH2:28][C:23]=3[O:22][N:21]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:26]3[CH2:27][CH2:28][C:23]4[O:22][N:21]=[C:20]([C:14]5[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=5)[C:24]=4[CH2:25]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 65016113-Phenyl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine

Product 1

HCID 59663063HCID 59663063, compoundYield 69%

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 3-Phenyl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine to provide the title compound.

Sources & evidence

ORD record
ord-fababe030d8e46c798991775f38e168d
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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