6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24900005, compound

HRID 550682Notes

Reaction equation

HRID 550682 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:23]2[C:22]([CH3:25])([CH3:24])[CH:21]=[CH:20][C:19]=2[CH2:18][CH2:17][NH:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH2:17][CH2:18][C:19]4[CH:20]=[CH:21][C:22]([CH3:25])([CH3:24])[C:23]=4[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 67193874HCID 67193874, compound

Product 1

HCID 24900005HCID 24900005, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 1,7,7-trimethyl-2,3,4,7-tetrahydro-1H-[2]pyrindine to provide the title compound.

Sources & evidence

ORD record
ord-358b795fa62346cf859f29f731ad48ba
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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