6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24900008, compound

HRID 550692Notes

Reaction equation

HRID 550692 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[Br:14][C:15]1[O:24][C:18]2[CH:19]([CH3:23])[NH:20][CH2:21][CH2:22][C:17]=2[CH:16]=1>>[Br:14][C:15]1[O:24][C:18]2[CH:19]([CH3:23])[N:20]([C:11]([C:9]3[CH:10]=[C:5]4[N:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]4[N:8]=3)=[O:13])[CH2:21][CH2:22][C:17]=2[CH:16]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 67193249HCID 67193249, compound

Product 1

HCID 24900008HCID 24900008, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 2-bromo-7-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine to provide the title compound.

Sources & evidence

ORD record
ord-3ea2ae73954d4e2bbd72746bf9de1126
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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