Ethyl 2-aminothiophene-3-carboxylate → 3-hydroxy-1H-thieno[2,3-d]pyrimidine-2,4-dione

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Reaction Steps

2-Amino-thiophene-3-carboxylic acid ethyl ester was transformed to the O-protected intermediate 3-(2,4-Dimethoxy-benzyloxy)-1H-thieno[2,3-d]pyrimidine-2,4-dione using general procedure A1. Deprotection of this intermediate using general procedure D1 gave the title compound which was purified by mass triggered preparative HPLC. 1H NMR (DMSO-d6) δ 10.39 (bs, 1H), 7.16 (d, 1H, J=5.7 Hz), 7.12 (d, 1H, J=5.7 Hz); Electrospray MS: 183 (M−H); retention time: 1.25 min.

Provenance & Evidence