ethyl 3-amino-5-phenylthiophene-2-carboxylate → 3-Hydroxy-6-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

3-Amino-5-phenyl-thiophene-2-carboxylic acid ethyl ester was converted to 3-(2,4-Dimethoxy-benzyloxy)-6-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione via general procedure A1. The intermediate was deprotected via general procedure D1 to give the title compound. 1H NMR (DMSO-d6) δ 10.50 (bs, 1H), 9.04 (s, 1H), 7.76-7.45 (m, 5H); Electrospray MS: 259 (M−H); retention time: 1.27 min.

Provenance & Evidence