Furan, 2-(bromomethyl)tetrahydro- → HCID 11551918, compound

Participants

Reaction Steps

3-(2,4-dimethoxy-benzyloxy)-6-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione (from previous example) was alkylated with 2-bromomethyl-tetrahydro-furan via general procedure B1. This crude intermediate was deprotected via general procedure D1 to give the title compound which was purified by mass-triggered preparative HPLC. 1H NMR (DMSO-d6) δ 7.80 (d, 2H, J=8.1 Hz), 7.78 (s, 1H), 7.52-7.44 (m, 3H), 4.23-4.06 (m, 3H), 3.74 (dd, 1H, J=7.8, 13.8 Hz), 3.59 (dd, 1H, J=7.5, 13.8 Hz), 2.05-1.58 (m, 4H); Electrospray MS: 345 (M+H); retention time: 2.43 min.

Provenance & Evidence