alpha-Bromo-o-chlorotoluene → HCID 11573144, compound

Participants

Reaction Steps

3-Allyloxy-1-(3-bromo-benzyl)-1H-thieno[3,2-d]pyrimidine-2,4-dione (from previous example) was alkylated with 1-bromomethyl-2-chloro-benzene via general procedure B2. The crude intermediate was deprotected via general procedure D2. The final product was purified by mass triggered preparative HPLC. 1H NMR (DMSO-d6) δ 10.65 (bs, 1H), 8.10 (d, 1H, J=5.1 Hz), 7.52 (dd, 1H, J=1.5, 7.8 Hz), 7.32 (dt, 1H, J=1.5, 7.5 Hz), 7.25 (dt, 1H, J=1.5, 7.5 Hz), 7.13 (d, 1H, J=5.4 Hz), 6.96 (dd, 1H, J=1.5, 7.5 Hz), 5.31 (s, 2H); Electrospray MS: 309 (M+H); retention time: 2.31 min.

Provenance & Evidence