Methyl iodide → 3-Hydroxy-1-methyl-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with methyl iodide according to procedure B2. The crude intermediate was deprotected via general procedure D1 to give the title compound which was purified by mass-triggered preparative HPLC. 1H NMR (d6-DMSO, 300 MHz) δ 3.76 (s, 3H); 7.33 (dd, J=7 Hz, 1H); 7.42 (dd, J=7 Hz, 1H); 7.93 (d, J=8 Hz, 1H); 8.27 (d, J=8 Hz, 1H); Retention time=1.81 min., m/z=249.0.

Provenance & Evidence