Benzyl Bromide → 1-Benzyl-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with benzyl bromide and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.75 (s, 2H); 7.20-7.45 (m, 6H); 7.56 (ddd, J1=8 Hz, J2=1 Hz, 1H); 7.93 (d, J=9 Hz, 1H); 8.15 (d, J=8 Hz, 1H); 11.06 (br s, 1H); retention time=2.57 min., m/z=325.0.

Provenance & Evidence