3-Bromobenzyl bromide → 1-(3-Bromo-benzyl)-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with 3-bromobenzyl bromide and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 7.10-7.18 (m, 2H); 7.22 (ddd, J1=8 Hz, J2=1 Hz, 1H); 7.31 (ddd, J1=7 Hz, J2=2 Hz, 1H); 7.39 (dd, J=8 Hz, 1H); 7.44 (s, 1H); 7.71 (d, J=8 Hz, 1H); 7.97 (d, J1=8 Hz, 1H); Ret. time=2.82 min., m/z=403.0.

Provenance & Evidence