HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-2-phenylbenzene → 1-Biphenyl-2-ylmethyl-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-2-phenylbenzene | HCID 263365 | — |
| Reactant | 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione | HCID 67200934 | — |
| Product | 1-Biphenyl-2-ylmethyl-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione | HCID 11582106 | — |
Reaction Steps
Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with 2-phenylbenzyl bromide and subsequently deptrotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.71 (s, 2H), 7.34 (d, J=8 Hz, 1H), 7.40-7.90 (m, 12H), 8.30 (d, J=8 Hz, 1H); Ret. time=3.22 min., m/z=399.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947691B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-e0c0b356aaba4649a70276ffbc785efb |
| Source note | uspto-grants-2011_05 |