Phenethyl bromide → 3-Hydroxy-1-phenethyl-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with 2-Bromoethylbenzene and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 3.08-3.14 (m, 2H); 4.67-4.73 (m, 2H); 7.24-7.38 (m, 5H); 7.61-7.69 (m, 2H); 8.20 (dd, J1=7 Hz, J2=2 Hz, 1H); 8.30 (dd, J1=7 Hz, J2=2 Hz, 1H); Ret. time=2.77 min., m/z=339.0.

Provenance & Evidence