2-Bromobenzyl bromide → HCID 11596531, compound

Participants

Reaction Steps

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with 2-bromobenzyl bromide and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.58 (s, 2H); 7.16-7.19 (m, 1H); 7.25-7.31 (m, 2H); 7.34-7.43 (m, 1H); 7.48-7.57 (m, 2H); 7.78-7.81 (m, 1H); 8.43 (d, J=8 Hz, 1H); 11.10 (br s, 1H); Ret. time=2.87 min., m/z=403.0.

Provenance & Evidence