HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → 1-Biphenyl-3-ylmethyl-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 1-(3-Bromo-benzyl)-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione | HCID 11682824 | — |
| Product | 1-Biphenyl-3-ylmethyl-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione | HCID 11531428 | — |
Reaction Steps
1-(3-Bromo-benzyl)-3-hydroxy-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was treated with phenylboronic acid according to general procedure C. The title compound was obtained as a yellow solid following purification by preparative HPLC. 1H NMR (d6-DMSO, 300 MHz) δ 5.79 (s, 2H); 7.26-7.69 (m, 10H); 8.00 (d, J=9 Hz, 1H); 8.13 (d, J=8 Hz, 2H); Ret. time=3.19 min., m/z=399.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947691B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-a51efa6b92394377b95696b8b10e39c8 |
| Source note | uspto-grants-2011_05 |