1-(Bromomethyl)-2-phenylbenzene → 1-Biphenyl-2-ylmethyl-3-hydroxy-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione was alkylated with 2-phenylbenzyl bromide and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.39 (s, 2H); 7.11 (d, J=7 Hz, 1H); 7.22-7.63 (m, 11H); 7.76 (d, J=8 Hz, 1H); Ret. time=3.01 min., m/z=383.0.

Provenance & Evidence