Propargyl bromide → 3-Hydroxy-1-prop-2-ynyl-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

Following general procedure B2 and D1, 3-(2,4-dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione was alkylated with an 80% solution of propargyl bromide in toluene and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 3.49 (t, J=2 Hz, 1H); 5.15 (d, J=2 Hz, 2H); 7.53 (dd, J=8 Hz, 1H); 7.70 (dd, J=8 Hz, 1H); 7.85 (d, J=8 Hz, 1H); 8.19 (d, J=8 Hz, 1H); Ret. time=1.86 min., m/z=257.0.

Provenance & Evidence