3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione → 3-Hydroxy-1-(1-phenyl-ethyl)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione

Participants

Role	Name	HCID	Charge
Reactant	3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione	HCID 67201879	—
Solvent	Benzene	HCID 241	—
Product	3-Hydroxy-1-(1-phenyl-ethyl)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione	HCID 11716772	—

Reaction Steps

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione was alkylated with 1-bromoethyl)benzene and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 1.98 (d, J=7 Hz, 3H); 6.32 (br s, 1H); 7.25-7.43 (m, 7H); 7.59 (dd, J=8 Hz, 1H); 7.81 (d, J=8 Hz, 1H); Ret. time=2.54 min., m/z=323.0.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07947691B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-525248dece6048af908182722eaf17e7
Source note	uspto-grants-2011_05