反应详情

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione was alkylated with trans-cinnamyl chloride and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.09 (s, 1H); 5.11 (s, 1H); 6.49-6.58 (m, 2H); 7.18-7.30 (m, 3H); 7.37-7.47 (m, 3H); 7.64 (dd, J=8 Hz, 1H); 7.82 (d, J=8 Hz, 1H); 8.07 (d, J=8 Hz, 1H), 10.73 (br s, 1H); Ret. time=2.66 min, m/z=333.0.