3-Bromobenzyl bromide → 1-(3-Bromo-benzyl)-3-hydroxy-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione

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Reaction Steps

Following general procedure B2 and D1, 3-(2,4-dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione was alkylated with 3-bromobenzyl bromide and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.55 (s, 2H); 7.25-7.40 (m, 3H); 7.42-7.52 (m, 1H); 7.57-7.63 (m, 2H); 7.76-7.85 (m, 2H); Ret. time=2.64 min., m/z=386.0.

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