Trifluoroacetic acid → HCID 15947351, compound

Participants

Reaction Steps

A mixture of 100 mg of 2-amino-6-chloro-4-(3-hydroxyphenyl)quinazoline hydrochloride, 90.69 mg of 5-(BOC-amino)-1-pentyl bromide, 100 mg of potassium carbonate and 1 ml of DMF is stirred at 40° for 16 hours. The mixture is dissolved in 2 ml of dichloromethane, 1 ml of TFA is added, and the mixture is stirred at room temperature for 4 hours. 3 ml of n-heptane are added, the solvents are removed in vacuo, and the residue is chromatographed, giving 67.9 mg (58.6%) of 2-amino-6-chloro-4-[3-(5-aminopentyloxy)phenyl]quinazoline (“A141”), MW 357.86.

Provenance & Evidence