HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-oxotetrahydrothiophene-3-carboxylate → HCID 178517533, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-oxotetrahydrothiophene-3-carboxylate | HCID 310629 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 59686263 | HCID 59686263 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178517533 | HCID 178517533 | — |
Reaction Steps
A mixture of 4-chloro-2,5-difluorobenzenecarboxamidine, ethyl 4-oxotetrahydrothiophene-3-carboxylate, NaOMe, and MeOH was stirred at ambient temperature for 19 hours and then at 60° C. for 5 hours to yield 2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4(1H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947690B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-ffeaf0188cfd4d248591c48ead162a9a |
| Source note | uspto-grants-2011_05 |