HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → HCID 67198373, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | HCID 67200022 | HCID 67200022 | — |
| Catalyst | Osmium Tetroxide | HCID 30318 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 67198373 | HCID 67198373 | — |
Reaction Steps
A tert-butanol solution of N-methylmorpholine-N-oxide and osmium tetraoxide was added to a mixture of 1-benzyl-4-methyleneazepane hydrochloride and THF-water, and the resultant solution was stirred at ambient temperature for 24 hours and then treated with 4M HCl-EtOAc solution to yield 1-benzyl-4-(hydroxymethyl)azepan-4-ol hydrochloride. To an EtOH solution of 1-benzyl-4-(hydroxymethyl)azepan-4-ol hydrochloride obtained was added 10% palladium on activated carbon, and the suspension was stirred under hydrogen atmosphere at ambient temperature for 6 hours to yield 4-(hydroxymethyl)azepan-4-ol hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947690B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-50c1de284acf4d4ca256fccda7c478e1 |
| Source note | uspto-grants-2011_05 |