HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-N,N-dimethylethylamine → HCID 58002057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-N,N-dimethylethylamine | HCID 7901 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58002057 | HCID 58002057 | — |
Reaction Steps
A mixture of 1-tert-butoxycarbonylpiperidin-4-ol, sodium hydride, and DMF was stirred at ambient temperature for 5 minutes, here was added 2-chloro-N,N-dimethylethylamine, and the mixture was further stirred at ambient temperature for 30 minutes to yield 2-[(1-tert-butoxycarbonylpiperidin-4-yl)oxy]-N,N-dimethylethylamine, which was stirred together with 4M HCl-dioxane solution at ambient temperature for 7 hours to yield N,N-dimethyl-2-(piperidin-4-yloxy)ethylamine dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947690B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-d0dd6b1c6112448a8700709d53409dab |
| Source note | uspto-grants-2011_05 |