反应详情

温度

25 °C

A solution of (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-carbamic acid phenyl ester (6 g, 19.8 mmol) and piperidin-4-yl-carbamic acid tert-butyl ester (4.37 g, 21.8 mmol) in acetonitrile (400 mL) was heated to reflux for 1 h and was then stirred at 25° C. overnight. The resulting solid was collected by filtration, rinsed with acetonitrile and dried in vacuo to afford [1-(7-methoxy-thiazolo[5,4-d]pyrimidin-2-ylcarbamoyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (7.3 g, 90%) as a white solid; ES-HRMS m/e calcd for C17H24N6O4S (M+H)+ 409.1653, found 409.1653.

1. temperatureto reflux for 1 h
2. filtrationThe resulting solid was collected by filtration
3. washrinsed with acetonitrile
4. customdried in vacuo