Water → HCID 59030252, compound

HRID 550877Notes

Reaction equation

HRID 550877 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([O:9][CH3:10])[C:3]=1[CH2:11][C:12]([O:14]C)=[O:13].[OH-].[K+].O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([O:9][CH3:10])[C:3]=1[CH2:11][C:12]([OH:14])=[O:13]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 59030280HCID 59030280, compound

Product 1

HCID 59030252HCID 59030252, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

75 g (328 mmol) of methyl 2-chloro-4-methyl-6-methoxyphenylacetate according to Ex. XXXI-1 are dissolved in 750 ml of methanol and then heated at 80° C. together with 55.20 g (984 mmol) of potassium hydroxide and 250 ml of water for 12 h. The methanol is removed using a rotary evaporator, the residue is adjusted to pH 3 and the precipitated product is filtered off and dried.

Workup

  1. customThe methanol is removed
  2. customa rotary evaporator
  3. filtrationthe precipitated product is filtered off
  4. customdried

Sources & evidence

ORD record
ord-23412ee2f64b4e5080b8dca8a0619515
Source dataset
uspto-grants-2011_05
Patent number
US07947704B2

Reaction notes

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